Endocrine Abstracts

Hypothyroidism is one of the most common endocrine disorders. The long-time debatable question is whether patients with subclinical hypothyroidism (SH) should be treated with levothyroxine. Data are contradictory and treatment decision depends on several factors: TSH level, anti-TPO level, age, presence of symptoms etc. Hypothyroidism is associated with cardiovascular disease. Even a minor increase in C-reactive protein (CRP) is considered a cardiovascular risk, therefore evid...

BackgroundType 2 diabetes has traditionally been considered a disease affecting older age groups. In recent years, however, Type 2 diabetes has become increasingly common in children, adolescents and young adults.Aim of the workTo estimate the prevalence of T2D among a sample of Egyptian youth aged (18–30) and to highlight the challenges in differentiating T1D from T2D in early onset diabetes depending o...

Background: One of the basic genetic factors that impact on development of diabetic nephropathy is enhanced expression of vascular endothelial growth factor (VEGF).Objective: To study association between VEGF polymorphism +405 G/C and early stage of chronic kidney disease (CKD) in patients with impaired glycemic states.Materials and methods: 73 included patients were divided into three groups: group 1–26 patients with prediabe...

Background: Lamin A/C mutations show heterogeneous phenotypes expanding from cardiopathies to lipodystrophies. LMNA-related heart disease has recently been shown to be associated with a high incidence of phenotypic progression and adverse arrhythmic and non-arrhythmic events. Anticipatory planning to prevent sudden death has been recommended in a multicentric cardiologic recruitment. Nevertheless the specific cardiac prognosis of R482-LMNA mutated patients, the hot-spot for pa...

Introduction: We designed this study, to investigate the effect of a single resistance exercise session on serum C-reactive protein (CRP) and cardiometabolic riskfactors in trained and untrained young healthy male students and to evaluate whether regular training may affect the response of these markers to exercise.Method: According to training status 34 healthy male students divided to 19 trained and 15 untrained groups. Each group was then randomly div...

Background: Thyroid function, insulin resistance, serum lipid, C-reactive protein (CRP) and homocysteine are associated with an increased cardiovascular risk in patients with autoimmune thyroiditis (AIT).Objective: To evaluate the interrelations between thyroid function, insulin resistance, serum lipid concentrations, CRP and homocysteine in patients with AIT and subclinical hypothyroidism.Subjects and methods: We recorded thyroid ...

Background: Anorexia is a problem of paramount importance in patients with advanced liver cirrhosis contributing to malnutrition. In turn, malnutrition is a risk factor for the development of life-threatening complications and increased mortality. Ghrelin hormone; an important orexigenic agent has been postulated to integrate anabolic changes in the body.Aim: To assess ghrelin level in Egyptian patients with liver cirrhosis and hepatocellular carcinoma.<...

Bone metabolism can be measured indirectly with specific biochemical markers. Desoxypyridinolin (DPD) is a derivate of hydroxypyridinium, which is discharged by bone resorption and is totally excreted urinary. A further marker of collagen resorption is the c-terminal telopeptide of collagen type I, which is liberated to blood circulation within the bone’s degradation and undergoes renal elimination. The aim of our investigation was to look after a correlation of these par...

Introduction: The standard treatment for differentiated thyroid carcinoma (DTC) with distant metastasis comprises complete total thyroidectomy and lymph node dissection, followed by radioactive iodine (RAI) ablation for metastatic lesions. However, between 2014 and 2015, sorafenib and lenvatinib have been approved for treatment of RAI-refractory advanced thyroid cancer in Japan. We retrospectively analyzed how the treatment results have changed after the approval of tyrosine k...

Background: Hepatitis C virus is common in Egypt and its prevalence varies from 10 to 17%. Beside its harmful effect on the liver, it can lead to variable other effects on various organs and tissues known as the extrahepatic manifestations of HCV. hepatitis C virus induced thyroid diseases in the form of thyroiditis resulting in hypofunction or even hyperfunction of the gland. thyroid disease was found to be of immune nature. Also diabetes which is often termed hepatogenous di...